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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC6
All Species:
18.18
Human Site:
T245
Identified Species:
36.36
UniProt:
Q96SB8
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SB8
NP_001135758.1
1091
126326
T245
H
Q
G
E
E
R
L
T
E
L
K
R
Q
C
V
Chimpanzee
Pan troglodytes
XP_001136387
1091
126280
T245
H
Q
G
E
E
R
L
T
E
L
K
R
Q
C
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532882
1606
180795
T760
N
Q
G
E
E
R
L
T
E
L
K
R
Q
C
L
Cat
Felis silvestris
Mouse
Mus musculus
Q924W5
1097
127179
T251
N
Q
G
E
E
R
L
T
E
L
K
R
Q
C
L
Rat
Rattus norvegicus
NP_001101484
1097
127259
T251
N
Q
G
E
E
R
L
T
E
L
K
R
Q
C
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505822
579
67328
Chicken
Gallus gallus
XP_419962
1096
127736
K253
E
Q
G
V
E
R
L
K
E
L
K
R
I
Y
C
Frog
Xenopus laevis
Q6P9I7
1128
130494
R284
E
N
G
G
E
R
L
R
D
L
R
Q
E
C
I
Zebra Danio
Brachydanio rerio
NP_001121806
1090
126266
L249
E
K
H
R
E
T
L
L
E
L
K
Q
K
F
R
Tiger Blowfish
Takifugu rubipres
Q802R8
1090
124790
K252
E
Q
H
S
E
C
L
K
D
L
K
R
D
Y
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794820
1236
142110
P327
D
A
Q
S
T
K
L
P
A
L
E
Y
E
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12749
1114
127990
K278
A
L
H
L
E
N
L
K
S
L
K
A
E
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
63.3
N.A.
90
90.4
N.A.
38.1
59.7
60.5
51.4
45.9
N.A.
N.A.
N.A.
30.2
Protein Similarity:
100
100
N.A.
66.1
N.A.
96.3
96.2
N.A.
44
77.9
76.7
70.3
67
N.A.
N.A.
N.A.
50.9
P-Site Identity:
100
100
N.A.
86.6
N.A.
86.6
86.6
N.A.
0
60
40
33.3
40
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
60
73.3
53.3
53.3
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
0
0
0
0
0
9
0
0
9
0
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
50
9
% C
% Asp:
9
0
0
0
0
0
0
0
17
0
0
0
9
0
0
% D
% Glu:
34
0
0
42
84
0
0
0
59
0
9
0
25
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
59
9
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
17
0
25
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% I
% Lys:
0
9
0
0
0
9
0
25
0
0
75
0
9
0
0
% K
% Leu:
0
9
0
9
0
0
92
9
0
92
0
0
0
0
42
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
25
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
59
9
0
0
0
0
0
0
0
0
17
42
0
0
% Q
% Arg:
0
0
0
9
0
59
0
9
0
0
9
59
0
0
9
% R
% Ser:
0
0
0
17
0
0
0
0
9
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
9
9
0
42
0
0
0
0
0
0
0
% T
% Val:
0
0
0
9
0
0
0
0
0
0
0
0
0
9
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _